Title Description
Star Product Yes
REF No 2001
Trademark GBL® ROSA-FIX
Product Name WEB İÇİN
Regulation
Purpose Methacarn Fixative is an alcohol-based fixative used in histology and molecular pathology studies where the preservation of nucleic acids and certain cellular antigens is important.
Working Principle Methanol rapidly stabilizes the cellular structure by coagulating proteins and stops enzymatic degradation. Chloroform increases tissue penetration by dissolving lipids and facilitates the fixative's access to intracellular components. Acetic acid is particularly effective on nuclear structures and contributes to the preservation of chromatin details. This combination allows nucleic acids to undergo less chemical modification compared to formalin, where protein cross-linking is intense; this provides an advantage in some molecular analyses.
Warnings, Precautions, Recommendations Danger. May cause serious eye damage and skin irritation. May cause respiratory tract irritation. The product may contain highly flammable solvents and toxic vapors; it may be harmful if swallowed, inhaled, or absorbed through the skin. Prolonged or intense exposure may cause adverse effects on the central nervous system. Avoid breathing the product's vapors, ensure the work area is well ventilated, and preferably use a chemical fume hood. Keep away from heat, sparks, and open flames. Chemical-resistant protective gloves, appropriate protective clothing, eye protection, and face protection equipment should be used during handling. If skin contact occurs, contaminated clothing should be removed and the affected area washed thoroughly with water. If inhaled, the person should be immediately removed to fresh air and kept in a position to breathe comfortably; seek medical attention if symptoms persist. In case of eye contact, eyes should be immediately and carefully rinsed with plenty of water for at least 15 minutes; if contact lenses are present and can be easily removed, they should be removed and rinsing continued; seek medical attention if irritation persists. If swallowed, do not induce vomiting and seek medical attention immediately. In all cases of exposure or suspected exposure, seek medical advice and show the product label or Safety Data Sheet to the healthcare professional. Due to flammable and volatile components, containers should be kept tightly closed and precautions should be taken against static electricity.
Ingredients Methanol, Chloroform, Acetic acid
Colour
Odour
Storage Temperature 15/25°C
Shelf Life After Opening the Lid
Shelf Life 2 years
pH (at 25°C)
Appearance
Concentration
Accessories
Application
Microbiological Properties
Ordering and Packaging Information
Order No Unit Volume Packaging Type
442001020500 Piece 500 mL 500 ml, White Bottle with HDPE Dropper

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